S-100 protein is a mixture of three proteins, that is. S-100 a0 (αα), S-100 a (αβ) and, S100 b (ββ). Twenty-two cases of sweat gland tumors were stained with immunoperoxidase technique (ABC method) for the presence of S-100α and β
subunits.
Four
syringomas, four eccirine poromas, two eccring porocarcinomas, two eccrine spiradenomas, one papillary eccrine adenoma, three clear cell hidradenomas, three mixed tumors of the skin, two papillary syringocystadenomas, and one cylindroma were
included.
All specimens were formalin-fixed and paraffin-embedded.
@ES The results were as follows :
@EN 1) The staining patterns of anti-S-100α and β protein antibodies were simillar to those of anti-S-100 protein antibody except in eccrine poroma and porocarcinoma.
2) In eccrine poroma and porocarcinoma, scattered S-100-positive dendritic cells within tumor cell nests were stained by S-100β protein antibody (3/6), but not by anti-S-100α protein antibody. S-100β is present in normal Langerhans cells.
Therefore
this finding suggests that these cells may be Langerhans cells.
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